She played both Ash’s companion and Team Rocket’s female lead from 1997 to 2015 across TV, film, and commercials. She also voiced some Pokémon like Jigglypuff and Goldeen, including in the Smash Bros. games.

Her sister Laurie Orr and her “Ash” co-star Veronica Taylor both confirmed the news. Here’s her IMDB page with other roles, including Your Lie in April and Hunter x Hunter.

Correction: Lillis was 55, not 46.